Tcell相关论文
The substantial advances attained by checkpoint blockade immunotherapies have driven an expansion in the approaches used......
The majority of colorectal cancer patients are not responsive to immune checkpoint blockade (ICB).The interferon gamma (......
Gut Microbiota Dysbiosis Strengthens Kupffer Cell-mediated Hepatitis B Virus Persistence through Ind
Background and Aims: Change of gut microbiota com-position is associated with the outcome of hepatitis B virus (HBV) inf......
Injury to peripheral nerves can lead to neuropathic pain,along with well-studied effects on sensory neurons,including hy......
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目的 T-cell based immunotherapy increasingly shows broad application prospects incancer treatment,but its performance in......
Objective Tumor has become a major diease that jeopardizes the world,and its occurrence and development are rlated to th......
Objective The leukocyte integrin LFA-1(CD11a/CD18),which belongs to the β 2 integrin family,is an adhesion factor and p......
The identification and pathological roles of IL-22 in acute graft-versus-host disease following allo
Aim: To explore the role of IL-22 in GVHD and the properties of IL-22-producing cells.Materials and Methods: GVHD mice m......
The immune responses of HLA-A*0201 restricted SARSCoV S peptide-specific CD8 T cells are augmented i
The induction of antigen specific memory CD8+ T cells in vivo is very important to new vaccines against infectious disea......
Aim: To investigate the expression and function of B ceil-activating factor (BAFF) and its receptors (BCMA, TACI, and BA......
The Phospholipid Scramblase 1 Enhances the Anti-tumour Responses of CD8+T Cells by regulating PI3K-A
T cells play important roles in antitumor immunity but they are often functionally exhausted in tumour microenvironment.......
Therapeutic effects of TACI-Ig on rats with adjuvant-induced arthritis via regulating T cell-mediate
OBJECTIVE To investigate the effects of TACI-Ig, a recombinant fusion protein that modulates B and T cells activation by......
S-nitrosoglutathione reductase deficiency ameliorates hyperhomocysteinemia-accelerated atheroscleros
Hyperhomocysteinemia(HHcy)is an independent risk factor for atherosclerosis.We have previously shown that T cell activat......
NSun2 deficiency ameliorates hyperhomocysteinemia-induced IL-17A secretion via suppressing mRNA meth
Hyperhomocysteinemia(HHcy)is an independent risk factor for atherosclerosis with high secretion of interleukin-17A(IL-17......
Homocysteine increased ER-mitochondrial coupling with promoting mitochondrial respiration and T cell
Homocysteine (Hcy) is a sulfur-containing non-constitutive amino acid derived from the essential amino acid methionine.N......
The induction of antigen specific memory CD8+ T cells in vivo is very important to new vaccines against infectious disea......
CD8+T cells have a central role in antitumor immunity,but their activity is suppressed in the tumor microenvironment.Rea......
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The variation of T-cell subsets in spleen and tissue histopathological changes in rats with adjuvant
Objective: To observe the variation of T-cell subsets in spleen in different course of disease and tissue histopathologi......
Tumor Associated Macrophage (TAM) Derived IL-6 Induced Re-localization of PD-L1 in Ovarian Cancer Ce
Objective: PD-L1 (also termed B7-H1) has been described to exert coinhibitory and immune regulatory functions.This study......
Abnormal expression of BLyS/APRIL and receptors in synovium tissue mediate T cell responses in adjuv
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目的:观察程序性细胞死亡受体-1/程序性细胞死亡受体配体-1（PD-1/PD-L1）调控树突状细胞（DC）对脓毒症患者免疫状态的影响，分析PD-1/PD-L1......
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Association between circulating CD39+CD8+ T cells prechemoradiotherapy and prognosis in patients wit
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Recipient dendritic cells modified by RNA interference targeting CD80 and CD86 elicit T cell hypores
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目的观察妊娠期母鼠感染疟原虫对子代鼠细胞免疫功能的影响，并研究胚胎期暴露疟原虫抗原的小鼠感染疟原虫后细胞免疫应答反应的变化......
目的探讨SLE患者外周血初始CD4+ T细胞的TGF-β受体Ⅰ（TGF-βRⅠ）mRNA表达水平和疾病活动的相关性。方法磁珠分选法分离纯化SLE患者......
Association between circulating CD39+CD8+ T cells prechemoradiotherapy and prognosis in patients wit
Background::The mortality rate among patients with nasopharyngeal carcinoma (NPC) has improved significantly with the ad......
共刺激分子4-1BB和4-1BB配体（4-1BBL）属于肿瘤坏死因子／肿瘤坏死因子受体（TNF／TN—FR）超家族的重要成员，分别表达在活化的T细胞及树突状细......
Expression of human T cell immunoglobulin domain and mucin-3(TIM-3)and TIM-3ligands in peripheral bl
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Aim: Natural killer (NK) cells are important innate effectors, and also have a role in shaping adaptive immune respo......
Human Prolactin Improves Engraftment and Reconstitution of Human Peripheral Blood Lymphocytes in SCI
Recombinant human prolactin (rhPRL) was administered to huPBL-SCID mice to determine its effects on human immunologic re......
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by anti-nuclear autoantibodies that cause dama......
Interferon (IFN)-γ, a potent proinflammatory cytokine produced by multiple types of cells (e.g., activated T, NK and NK......
Soluble Mouse B7-H3 Down-Regulates Dendritic Cell Stimulatory Capacity to Allogenic T Cell Prolifera
B7-H3 is a recently identified member of the B7 gene family. Its ubiquitous expression in both lymphoid and nonlymphoid ......
Thymic stromal lymphopoietin (TSLP), an IL-7-related cytokine, is widely expressed by epithelial cells in many tissues w......
树突状细胞(DC)是一类专职的抗原递呈细胞,广泛分布于血液、肝、脾、淋巴结及其他非免疫器官组织中.DC表达丰富的MHC分子、粘附分......
利妥昔单抗注射液作为最早应用于临床的CD20单抗类药物，广泛用于CD20阳性的淋巴瘤和一些自身免疫性疾病的治疗。近年的研究发现，该药......
随着肿瘤免疫学理论和技术的不断发展,人们对肿瘤的认识和治疗也迎来了新纪元.除了传统的手术、放疗和化疗以外,以嵌合抗原受体修......
Objective: To observe the effects of electro-acupuncture on T cell subpopulations, natural killer cell (NK)activity, hum......
经典的免疫学理论认为，B淋巴细胞对胸腺依赖性抗原（thymus dependent antigen，TD）的应答必须要有Th细胞的辅助［1］。在B淋巴细胞的活化及......
感染性疾病可由多种病原体感染人体引起,人体感染病原体后可产生特异性免疫反应.T细胞产生的免疫应答是细胞免疫,在人体抗感染中发......
1995年Sakaguchi等首次分离获得具有免疫调节作用的CD4+CD25+细胞,称之为调节性T细胞(regulatory T cell,Treg),在自身免疫疾病、......
AIM: Quasispecies of hepatitis C virus (HCV) are the foundation for rapid sequence evolution of HCV to evade immune surv......
AIM: To evaluate, whether humoral hepatitis-B-vaccine non-responders also fail to mount a T cell response and to compare......
